Scientific Advisory Board

 

DUOJIA PAN, PH.D.

Fouad A. and Val Imm Bashour Distinguished Chair in Physiology
Investigator, Howard Hughes Medical Institute
Professor of Physiology, The University of Texas Southwestern Medical Center

Dr. Pan obtained B.S. in Biochemistry from Peking University and Ph.D. in Biological Chemistry from UCLA. After a postdoctoral fellowship with Gerald Rubin at UC Berkeley, Dr. Pan joined the faculty at UT Southwestern in 1998 and Johns Hopkins University in 2004. He returned to UT Southwestern Medical Center in 2016 to become the new Chairman of the Department of Physiology. Dr. Pan’s lab focuses on the molecular mechanisms of growth control and tissue homeostasis. He is best known for pioneering work on the Hippo signaling pathway, an evolutionarily conserved developmental pathway that controls organ size in all animals. Using Drosophila as a model, his laboratory made a series of discoveries that defined, in a stepwise manner, the key molecular events in the Hippo signaling pathway. His team further established a critical role for the Hippo pathway in controlling mammalian organ size, regeneration and tumorigenesis. Besides research on the Hippo pathway, his laboratory also elucidated the molecular function of the Tsc1 and Tsc2 tumor suppressor genes, linking Tsc1/Tsc2 to Rheb and TOR signaling. This work provided the key molecular insight for the use of mTOR inhibitors in the treatment of Tuberous Sclerosis. Dr. Pan is a Fellow of the American Association for Advancement of Science and a recipient of the Paul Marks Prize for Cancer Research.