Scientific Advisory Board



Director, Jonsson Center for Research in Molecular Genetics 
Paul J. Thomas Professor of Molecular Genetics
Regental Professor, The University of Texas Southwestern Medical Center


Michael S. Brown, M.D. is Regental Professor, Paul J. Thomas Professor of Molecular Genetics, and Director of the Jonsson Center for Research in Molecular Genetics at UT Southwestern Medical Center. He and his long-time colleague, Dr. Joseph L. Goldstein, together discovered the low density lipoprotein (LDL) receptor which controls the level of cholesterol in blood and in cells. They showed that mutations in this receptor cause familial hypercholesterolemia, a disorder that leads to premature heart attacks in one out of every 500 people in most populations. Drs. Brown and Goldstein have received many awards for this work, including the Nobel Prize for Physiology or Medicine (1985), the Albert D. Lasker Prize in Basic Medical Research (1985), and the U.S. National Medal of Science (1988). Dr. Brown received a B.A. in chemistry and an M.D. from the University of Pennsylvania. He was an intern and resident at Massachusetts General Hospital and a postdoctoral fellow at the National Institutes of Health before relocating to Dallas in 1971 to join the faculty at UT Southwestern. Dr. Brown is a member of the National Academy of Sciences, the Institute of Medicine, The Royal Society (London), the Association of American Physicians, and The American Society for Clinical Investigation.